Larsens Syndrome is a connective tissue disorder mainly affecting the major joints of the body. It can cause hyper-mobility and congenital joint dislocations. Characteristics can also include spinal defects, cleft palate, malformations of the feet, severe reflux, tracheomalacia, and other unusual features in the face, hands, and bones.
For Belli specifically is caused bilateral knee and hip dislocations, feet malformations, mild reflux, and spinal problems.
Larsens Syndrome is caused by a mutation on the Filamin B gene located on the third chromosome. It is most often inherited but there are some cases of sporadic mutations.